I took one trip in February with my boss in his plane to Seattle. It was up and back the same day, from Centennial Airport to Boeing Field. I don’t like so much overnight business trips and try as much as I can to schedule day trips only. From Denver, it is very doable to many destinations.
Very smooth flight up and back with snow and precipitation in Seattle. Some bumps on our return into Denver, but nothing nerve-wracking. Any route that brings you back over the Indian Peaks Wilderness Area into Denver can be pretty bumpy, in me experience, which is the most direct route back from Seattle. Trip map below.
View in Google Earth (KMZ file)